Robustness of neuronal excitability and function across gender and lifespan

Universite de Lyon 1, France

We want to understand how cellular physiology is controled by basic molecular and cellular pathways regulating the biology of potassium-selective ion channels. Recent advances in single-cell transcriptomics have revealed a rich combinatorial code of potassium channels in the nervous system of C. elegans. Combined with the powerful genetic tools available in worms, this knowledge allows us now to directly ask how the electrical identity of neurons is established, how it is maintained, and how it can change with life experience or differ in male/female brains. As a member of the MeLiS laboratory and the Labex CORTEX initiative, we are embedded in the rich neuroscience environment of Lyon (France). We have ongoing collaborations with national and international partners on basic and applied research topics.

Research team webpage: http://www.excitingworms.eu/